(S)-GSK1379725A
Product Specifications
UNSPSC Description
(S)-GSK1379725A (compound AU1) is a selective bromodomain and PHD finger containing transcription factor (BPTF) bromodomain inhibitor with a Kd of 2.8 μM. (S)-GSK1379725A shows to be selective for BPTF over BRD4 bromodomain. (S)-GSK1379725A shows antimalarial activity[1].
Target Antigen
Epigenetic Reader Domain; Parasite
Type
Reference compound
Related Pathways
Anti-infection;Epigenetics
Applications
COVID-19-immunoregulation
Field of Research
Infection
Assay Protocol
https://www.medchemexpress.com/s-gsk1379725a.html
Solubility
10 mM in DMSO
Smiles
COC(C1=CC=CC(NC(N[C@@H](CC2)CN2C3=NC(NC4=CC=C(C=C4)F)=NC=C3)=O)=C1)=O
Molecular Weight
450.47
References & Citations
[1]Steven E Kirberger, et al. Selectivity, ligand deconstruction, and cellular activity analysis of a BPTF bromodomain inhibitor. Org Biomol Chem. 2019 Feb 13;17(7):2020-2027.
Shipping Conditions
Room temperature
Product Datasheet
http://file.medchemexpress.com/batch_PDF/HY-145431/S-GSK1379725A-DataSheet-MedChemExpress.pdf
Product MSDS
http://file.medchemexpress.com/batch_PDF/HY-145431/
Clinical Information
No Development Reported
CAS Number
2359618-49-6
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