(S) -GSK1379725A

(S) -GSK1379725A (compound AU1) is a selective bromodomain and PHD finger containing transcription factor (BPTF) bromodomain inhibitor with a Kd of 2.8 μM. (S) -GSK1379725A shows to be selective for BPTF over BRD4 bromodomain. (S) -GSK1379725A shows antimalarial activity[1].

Product Specifications

CAS Number

[2359618-49-6]

UNSPSC

12352005

Target

Epigenetic Reader Domain; Parasite

Type

Reference compound

Related Pathways

Anti-infection; Epigenetics

Applications

COVID-19-immunoregulation

Field of Research

Infection

Assay Protocol

https://www.medchemexpress.com/s-gsk1379725a.html

Solubility

10 mM in DMSO

Smiles

COC(C1=CC=CC(NC(N[C@@H](CC2)CN2C3=NC(NC4=CC=C(C=C4)F)=NC=C3)=O)=C1)=O

Molecular Formula

C23H23FN6O3

Molecular Weight

450.47

References & Citations

[1]Steven E Kirberger, et al. Selectivity, ligand deconstruction, and cellular activity analysis of a BPTF bromodomain inhibitor. Org Biomol Chem. 2019 Feb 13;17 (7) :2020-2027.