IRE1α kinase-IN-5
IRE1α kinase-IN-5 (compound 7) is a potent IRE1α inhibitor with an Ki of 98 nM. IRE1α kinase-IN-5 is the ATP-competitive ligands of IRE1α[1].
Product Specifications
CAS Number
[2771006-47-2]
UNSPSC
12352005
Target
IRE1
Type
Reference compound
Related Pathways
Cell Cycle/DNA Damage
Applications
Cancer-Kinase/protease
Field of Research
Others
Assay Protocol
https://www.medchemexpress.com/ire1α-kinase-in-5.html
Solubility
10 mM in DMSO
Smiles
O=S(NC(C1=C2C=CC=C1)=CC=C2OC3=NC=CC=C3C4=NC(N[C@H]5CC[C@H](N)CC5)=NC=C4)(C6CC6)=O
Molecular Formula
C28H30N6O3S
Molecular Weight
530.64
References & Citations
[1]Feldman HC, et al. ATP-competitive partial antagonists of the IRE1α RNase segregate outputs of the UPR. Nat Chem Biol. 2021 Nov;17 (11) :1148-1156.
Shipping Conditions
Room temperature
Scientific Category
Reference compound1
Clinical Information
No Development Reported
Curated Selection
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