JAK1/TYK2-IN-1
JAK1/TYK2-IN-1 is a dual inhibitor of TYK2 and JAK1 (IC50 = 29 and 41 nM respectively) .
Product Specifications
CAS Number
[1883300-48-8]
UNSPSC
12352005
Target
JAK
Type
Reference compound
Related Pathways
Epigenetics; JAK/STAT Signaling; Protein Tyrosine Kinase/RTK; Stem Cell/Wnt
Applications
Cancer-Kinase/protease
Field of Research
Cancer
Assay Protocol
https://www.medchemexpress.com/jak1-tyk2-in-1.html
Solubility
10 mM in DMSO
Smiles
O=C([C@H]1C(F)(C1)F)N[C@]23[C@](CN(C4=NC(NC5=CN(C)N=C5)=NC=C4F)C3)([H])[C@H]2C
Molecular Formula
C18H20F3N7O
Molecular Weight
407.39
References & Citations
[1]Fensome A, et al. Design and optimization of a series of 4- (3-azabicyclo[3.1.0]hexan-3-yl) pyrimidin-2-amines: Dual inhibitors of TYK2 and JAK1. Bioorg Med Chem. 2020 May 15;28 (10) :115481.
Shipping Conditions
Room temperature
Scientific Category
Reference compound1
Clinical Information
No Development Reported
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