JAK1/TYK2-IN-1
Product Specifications
UNSPSC Description
JAK1/TYK2-IN-1 is a dual inhibitor of TYK2 and JAK1 (IC50 = 29 and 41 nM respectively).
Target Antigen
JAK
Type
Reference compound
Related Pathways
Epigenetics;JAK/STAT Signaling;Protein Tyrosine Kinase/RTK;Stem Cell/Wnt
Applications
Cancer-Kinase/protease
Field of Research
Cancer
Assay Protocol
https://www.medchemexpress.com/jak1-tyk2-in-1.html
Solubility
10 mM in DMSO
Smiles
O=C([C@H]1C(F)(C1)F)N[C@]23[C@](CN(C4=NC(NC5=CN(C)N=C5)=NC=C4F)C3)([H])[C@H]2C
Molecular Weight
407.39
References & Citations
[1]Fensome A, et al. Design and optimization of a series of 4-(3-azabicyclo[3.1.0]hexan-3-yl)pyrimidin-2-amines: Dual inhibitors of TYK2 and JAK1. Bioorg Med Chem. 2020 May 15;28(10):115481.
Shipping Conditions
Room temperature
Product Datasheet
http://file.medchemexpress.com/batch_PDF/HY-145336/JAK1-TYK2-IN-1-DataSheet-MedChemExpress.pdf
Product MSDS
http://file.medchemexpress.com/batch_PDF/HY-145336/
Clinical Information
No Development Reported
CAS Number
1883300-48-8
Curated Selection
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