OKI-006

OKI-006 is a potent and orally active inhibitor of histone deacetylase (HDAC) . OKI-006 is a unique congener of the natural product HDAC inhibitor largazole. Histone deacetylases (HDACs) play critical roles in epigenomic regulation, and histone acetylation is dysregulated in many human cancers. OKI-006 has the potential for the research of cancer disease[1].

Product Specifications

CAS Number

[1315334-23-6]

UNSPSC

12352005

Target

HDAC

Type

Reference compound

Related Pathways

Cell Cycle/DNA Damage; Epigenetics

Applications

Cancer-programmed cell death

Field of Research

Cancer

Assay Protocol

https://www.medchemexpress.com/oki-006.html

Solubility

10 mM in DMSO

Smiles

SCC/C=C/[C@@H]1CC(NCC2=NC(C(NC(C)(C(N[C@H](C(O1)=O)C(C)C)=O)C)=O)=CS2)=O

Molecular Formula

C21H30N4O5S2

Molecular Weight

482.62

References & Citations

[1]Diamond JR, et al. Preclinical Development of the Class-I-Selective Histone Deacetylase Inhibitor OKI-179 for the Treatment of Solid Tumors. Mol Cancer Ther. 2022;21 (3) :397-406.