MGlu4 receptor agonist 1

MGlu4 receptor agonist 1 (compound 62) is a potent mGlu4 receptor positive allosteric modulator, with an EC50 of 308 nM. mGlu4 receptor agonist 1 shows significant anxiolytic- and antipsychotic-like effect[1].

Product Specifications

CAS Number

[1678501-16-0]

UNSPSC

12352005

Target

MGluR

Type

Reference compound

Related Pathways

GPCR/G Protein; Neuronal Signaling

Applications

Neuroscience-Neuromodulation

Field of Research

Neurological Disease

Assay Protocol

https://www.medchemexpress.com/mglu4-receptor-agonist-1.html

Solubility

10 mM in DMSO

Smiles

CC1=CC(NC(C2=CC=CC=N2)=O)=CC=C1C3=NOC(C4=C(C=CC=C4)Cl)=N3

Molecular Formula

C21H15ClN4O2

Molecular Weight

390.82

References & Citations

[1]Stankiewicz A, et al. New 1,2,4-oxadiazole derivatives with positive mGlu4 receptor modulation activity and antipsychotic-like properties. J Enzyme Inhib Med Chem. 2022 Dec;37 (1) :211-225.