ATM Inhibitor-2

ATM Inhibitor-2 (compound 7) is a potent and selective ATM inhibitor, with an IC50 of [1].

Product Specifications

CAS Number

[2769140-29-4]

UNSPSC

12352005

Target

ATM/ATR

Type

Reference compound

Related Pathways

Cell Cycle/DNA Damage; PI3K/Akt/mTOR

Applications

Cancer-Kinase/protease

Field of Research

Cancer

Assay Protocol

https://www.medchemexpress.com/atm-inhibitor-2.html

Solubility

10 mM in DMSO

Smiles

CN(CCNC(NC1=CC=C(C=N1)C2=CC=C3N=CC4=C(N(C(N4C)=O)C5CCOCC5)C3=C2)=O)C

Molecular Formula

C26H31N7O3

Molecular Weight

489.57

References & Citations

[1]Dimitrov T, et al. Development of novel urea-based ATM kinase inhibitors with subnanomolar cellular potency and high kinome selectivity. Eur J Med Chem. 2022 May 5;235:114234.

Shipping Conditions

Room temperature

Scientific Category

Reference compound1

Clinical Information

No Development Reported

Isoform

ATM

Curated Selection

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