ATM Inhibitor-2
ATM Inhibitor-2 (compound 7) is a potent and selective ATM inhibitor, with an IC50 of [1].
Product Specifications
CAS Number
[2769140-29-4]
UNSPSC
12352005
Target
ATM/ATR
Type
Reference compound
Related Pathways
Cell Cycle/DNA Damage; PI3K/Akt/mTOR
Applications
Cancer-Kinase/protease
Field of Research
Cancer
Assay Protocol
https://www.medchemexpress.com/atm-inhibitor-2.html
Solubility
10 mM in DMSO
Smiles
CN(CCNC(NC1=CC=C(C=N1)C2=CC=C3N=CC4=C(N(C(N4C)=O)C5CCOCC5)C3=C2)=O)C
Molecular Formula
C26H31N7O3
Molecular Weight
489.57
References & Citations
[1]Dimitrov T, et al. Development of novel urea-based ATM kinase inhibitors with subnanomolar cellular potency and high kinome selectivity. Eur J Med Chem. 2022 May 5;235:114234.
Shipping Conditions
Room temperature
Scientific Category
Reference compound1
Clinical Information
No Development Reported
Isoform
ATM
Curated Selection
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