DNA-PK-IN-4
DNA-PK-IN-4 is a potent inhibitor of DNA-PK. DNA-PK-IN-4 is a imidazolinone derivative compound. DNA-PK-IN-4 inhibits DNA-PKcs activity, thus greatly reducing tumor DNA repair and inducing cells to enter the apoptotic program. DNA-PK-IN-4 has the potential for the research of cancer disease (extracted from patent WO2021209055A1, compound 27) [1].
Product Specifications
CAS Number
[2722645-10-3]
UNSPSC
12352005
Target
DNA-PK
Type
Reference compound
Related Pathways
Cell Cycle/DNA Damage; PI3K/Akt/mTOR
Applications
Cancer-Kinase/protease
Field of Research
Cancer
Assay Protocol
https://www.medchemexpress.com/dna-pk-in-4.html
Solubility
10 mM in DMSO
Smiles
O=C(NC)C1=CC=C(NC2=NC=C3N(C)C(N(C4CCOCC4)C3=N2)=O)C(C)=C1
Molecular Formula
C20H24N6O3
Molecular Weight
396.44
References & Citations
[1]Yonggang Wei, et al. Imidazolinone derivatives and their applications in medicine. Patent WO2021209055A1.
Shipping Conditions
Room temperature
Scientific Category
Reference compound1
Clinical Information
No Development Reported
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