NN-390
Product Specifications
UNSPSC Description
NN-390 is a potent and selective HDAC6 inhibitor, with an IC50 of 9.8 nM. NN-390 penetrates the blood-brain barrier (BBB). NN-390 shows study potential in metastatic Group 3 MB (medulloblastoma)[1].
Target Antigen
HDAC
Type
Reference compound
Related Pathways
Cell Cycle/DNA Damage;Epigenetics
Applications
Cancer-programmed cell death
Field of Research
Cancer
Assay Protocol
https://www.medchemexpress.com/nn-390.html
Solubility
10 mM in DMSO
Smiles
O=C(NO)C1=CC=C(CN(C(C)C)S(=O)(C2=CC(F)=C(F)C(F)=C2F)=O)C=C1
Molecular Weight
420.38
References & Citations
[1]Nawar N, Bukhari S, Adile AA, et al. Discovery of HDAC6-Selective Inhibitor NN-390 with in Vitro Efficacy in Group 3 Medulloblastoma. J Med Chem. 2022;65(4):3193-3217.
Shipping Conditions
Room temperature
Product Datasheet
http://file.medchemexpress.com/batch_PDF/HY-143877/NN-390-DataSheet-MedChemExpress.pdf
Product MSDS
http://file.medchemexpress.com/batch_PDF/HY-143877/
Clinical Information
No Development Reported
CAS Number
2490284-25-6
Curated Selection
Explore Other Products
Discover premium biology products from our extensive collection of 20M+ items
MBS1046035 Inquire
Recombinant Meleagris gallopavo Type-1 angiotensin II receptor (AGTR1)
Ask
View Details 
