GPP78

GPP78 (CAY10618) is a potent Nampt inhibitor with an IC50 of 3.0 nM for nicotinamide adenine dinucleotide (NAD) depletion. GPP78 is cytotoxic to neuroblastoma cell line SH-SY5Y cells with an IC50 of 3.8 nM by inducing autophagy. GPP78 has anti-cancer and anti-inflammatory effects[1][2].

Product Specifications

CAS Number

[1202580-59-3]

Product Name Alternative

CAY10618

UNSPSC

12352005

Hazard Statement

H302, H315, H319, H335

Target

Autophagy; NAMPT

Type

Reference compound

Related Pathways

Autophagy; Metabolic Enzyme/Protease

Applications

Neuroscience-Neuromodulation

Field of Research

Cancer; Inflammation/Immunology

Assay Protocol

https://www.medchemexpress.com/gpp78.html

Concentration

11.38 mM * 1 mL in Methanol

Purity

99.0

Solubility

10 mM in DMSO

Smiles

O=C(CCCCCCCN1N=NC(C2=CN=CC=C2)=C1)NC3=CC=CC=C3C4=CC=CC=C4

Molecular Formula

C27H29N5O

Molecular Weight

439.55

Precautions

H302, H315, H319, H335

References & Citations

[1]Colombano G, et al. A novel potent nicotinamide phosphoribosyltransferase inhibitor synthesized via click chemistry. J Med Chem. 2010 Jan 28;53 (2) :616-23.|[2]Esposito E, et al. The NAMPT inhibitor FK866 reverts the damage in spinal cord injury. J Neuroinflammation. 2012 Apr 10;9:66.