SCP1-IN-2
Product Specifications
UNSPSC Description
SCP1-IN-2 (Compound SH T-65) is a potent and selective covalent inhibitor against SCP1. SCP1-IN-2 promotes REST degradation and reduces transcriptional activity. A high level of REST protein drives the tumor growth in some glioblastoma cells. SCP1-IN-2 has the potential for the research of glioblastoma whose growth is driven by REST transcription activity[1].
Target Antigen
Phosphatase
Type
Reference compound
Related Pathways
Metabolic Enzyme/Protease
Applications
Cancer-programmed cell death
Field of Research
Cancer; Neurological Disease
Assay Protocol
https://www.medchemexpress.com/scp1-in-2.html
Solubility
10 mM in DMSO
Smiles
O=S1(C2=CC=CC=C2C=C1C(NCCCNS(C3=CC=C(C=C3)OC(F)(F)F)(=O)=O)=O)=O
Molecular Weight
490.47
References & Citations
[1]Medellin B, et al. Targeted Covalent Inhibition of Small CTD Phosphatase 1 to Promote the Degradation of the REST Transcription Factor in Human Cells. J Med Chem. 2022;65(1):507-519.
Shipping Conditions
Room temperature
Product Datasheet
http://file.medchemexpress.com/batch_PDF/HY-142683/SCP1-IN-2-DataSheet-MedChemExpress.pdf
Product MSDS
http://file.medchemexpress.com/batch_PDF/HY-142683/
Clinical Information
No Development Reported
CAS Number
2764615-56-5
Curated Selection
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