Ribostamycin
Product Specifications
UNSPSC Description
Ribostamycin (Vistamycin) is a broad-spectrum aminoglycoside antibiotic. Ribostamycin is effective against Gram-Negative and Gram-Positive bacterial infection. Ribostamycin also inhibits the chaperone activity of PDI[1][2].
Target Antigen
Antibiotic; Bacterial; PDI
Type
Natural Products
Related Pathways
Anti-infection;Cell Cycle/DNA Damage;Metabolic Enzyme/Protease
Applications
COVID-19-anti-virus
Field of Research
Infection
Assay Protocol
https://www.medchemexpress.com/ribostamycin.html
Solubility
10 mM in DMSO
Smiles
NC[C@H]([C@H]([C@@H]([C@H]1N)O)O)O[C@@H]1O[C@H]([C@H](C[C@H]([C@@H]2O)N)N)[C@@H]2O[C@@H]3O[C@@H]([C@H]([C@H]3O)O)CO
Molecular Weight
454.47
References & Citations
[1]Zheng T, et al. Linear self-assembly formation between gold nanoparticles and aminoglycoside antibiotics. Colloids Surf B Biointerfaces. 2018 Apr 1;164:185-191. |[2]Hunfeld KP, et al. In vitro activity of mezlocillin, meropenem, aztreonam, vancomycin, teicoplanin, ribostamycin and fusidic acid against Borrelia burgdorferi. Int J Antimicrob Agents. 2001 Mar;17(3):203-8.|[3]Horibe T, et al. Ribostamycin inhibits the chaperone activity of protein disulfide isomerase. Biochem Biophys Res Commun. 2001 Dec 21;289(5):967-72. |[4]Kong J, et al. Exploration of Antibiotic Activity of Aminoglycosides, in Particular Ribostamycin Alone and in Combination With Ethylenediaminetetraacetic Acid Against Pathogenic Bacteria. Front Microbiol. 2020 Jul 29;11:1718. |[5]Kitasato I, et al. Comparative nephrotoxicity of ribostamycin and gentamicin in rats evaluated by urinalysis. Drugs Exp Clin Res. 1989;15(6-7):273-89.
Shipping Conditions
Room temperature
Product Datasheet
http://file.medchemexpress.com/batch_PDF/HY-142127/Ribostamycin-DataSheet-MedChemExpress.pdf
Product MSDS
http://file.medchemexpress.com/batch_PDF/HY-142127/
Clinical Information
No Development Reported
CAS Number
25546-65-0
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