N-(Azido-PEG3)-N-bis(PEG1-t-butyl ester)
Product Specifications
UNSPSC Description
N-(Azido-PEG3)-N-bis(PEG1-t-butyl ester) is a PEG-based PROTAC linker that can be used in the synthesis of PROTACs[1]. N-(Azido-PEG3)-N-bis(PEG1-t-butyl ester) is a click chemistry reagent, it contains an Azide group and can undergo copper-catalyzed azide-alkyne cycloaddition reaction (CuAAc) with molecules containing Alkyne groups. It can also undergo strain-promoted alkyne-azide cycloaddition (SPAAC) reactions with molecules containing DBCO or BCN groups.
Target Antigen
PROTAC Linkers
Type
Reference compound
Related Pathways
PROTAC
Applications
Cancer-programmed cell death
Field of Research
Cancer
Assay Protocol
https://www.medchemexpress.com/n-azido-peg3-n-bis-peg1-t-butyl-ester.html
Solubility
10 mM in DMSO
Smiles
O=C(OC(C)(C)C)CCOCC(COCCC(OC(C)(C)C)=O)NC(CCOCCOCCOCCN=[N+]=[N-])=O
Molecular Weight
576.68
References & Citations
[1]An S, et al. Small-molecule PROTACs: An emerging and promising approach for the development of targeted therapy drugs. EBioMedicine. 2018 Oct;36:553-562
Shipping Conditions
Room temperature
Product Datasheet
http://file.medchemexpress.com/batch_PDF/HY-140873/N-Azido-PEG3-N-bis-PEG1-t-butyl-ester-DataSheet-MedChemExpress.pdf
Product MSDS
http://file.medchemexpress.com/batch_PDF/HY-140873/
Clinical Information
No Development Reported
CAS Number
2086689-00-9
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