DBCO-PEG4-alcohol

DBCO-PEG4-alcohol is a PEG-based PROTAC linker that can be used in the synthesis of PROTACs[1]. DBCO-PEG4-alcohol is a click chemistry reagent, it contains a DBCO group that can undergo strain-promoted alkyne-azide cycloaddition (SPAAC) with molecules containing Azide groups.

Product Specifications

CAS Number

[1416711-60-8]

UNSPSC

12352005

Hazard Statement

H302, H315, H319, H335

Target

PROTAC Linkers

Type

Reference compound

Related Pathways

PROTAC

Applications

Cancer-programmed cell death

Field of Research

Cancer

Assay Protocol

https://www.medchemexpress.com/dbco-peg4-alcohol.html

Purity

95.17

Solubility

10 mM in DMSO

Smiles

O=C(N1C2=CC=CC=C2C#CC3=CC=CC=C3C1)CCCCC(NCCOCCOCCOCCO)=O

Molecular Formula

C29H36N2O6

Molecular Weight

508.61

Precautions

H302, H315, H319, H335

References & Citations

[1]An S, et al. Small-molecule PROTACs: An emerging and promising approach for the development of targeted therapy drugs. EBioMedicine. 2018 Oct;36:553-562