Amino-PEG6-Thalidomide

Amino-PEG6-Thalidomide is a PEG-based PROTAC linker that can be used in the synthesis of PROTACs[1].

Product Specifications

UNSPSC

12352005

Hazard Statement

H302-H315-H319-H335

Target

Apoptosis; Autophagy; E3 Ligase Ligand-Linker Conjugates

Type

Reference compound

Related Pathways

Apoptosis; Autophagy; PROTAC

Applications

Cancer-programmed cell death

Field of Research

Cancer

Assay Protocol

https://www.medchemexpress.com/amino-peg6-thalidomide.html

Solubility

10 mM in DMSO

Smiles

O=C1N(C2C(N(CCOCCOCCOCCOCCOCCOCCN)C(CC2)=O)=O)C(C3=CC=CC=C31)=O

Molecular Formula

C27H39N3O10

Molecular Weight

565.61

Precautions

P261-P264-P270-P271-P280-P302+P352-P304+P340-P305+P351+P338-P330-P362+P364-P403+P233-P405-P501

References & Citations

[1]An S, et al. Small-molecule PROTACs: An emerging and promising approach for the development of targeted therapy drugs. EBioMedicine. 2018 Oct;36:553-562

Shipping Conditions

Room temperature

Scientific Category

Reference compound1

Clinical Information

No Development Reported

Isoform

Cereblon

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