PC DBCO-PEG3-biotin
PC DBCO-PEG3-biotin is a cleavable 3 unit PEG ADC linker used in the synthesis of antibody-drug conjugates (ADCs) [1]. PC DBCO-PEG3-biotin is a click chemistry reagent, it contains a DBCO group that can undergo strain-promoted alkyne-azide cycloaddition (SPAAC) with molecules containing Azide groups.
Product Specifications
UNSPSC
12352203
Hazard Statement
H302-H315-H319-H335
Target
ADC Linker
Type
ADC Related
Related Pathways
Antibody-drug Conjugate/ADC Related
Applications
Cancer-programmed cell death
Field of Research
Cancer
Assay Protocol
https://www.medchemexpress.com/pc-dbco-peg3-biotin.html
Solubility
10 mM in DMSO
Smiles
[H][C@@]1(N2)CS[C@@H]([C@](NC2=O)1[H])CCCCC(NCCOCCOCCOCCNC(CCCOC(C=C3[N+]([O-])=O)=C(C=C3C(C)OC(NCCC(N4C5=CC=CC=C5C#CC6=CC=CC=C6C4)=O)=O)OC)=O)=O
Molecular Formula
C50H63N7O13S
Molecular Weight
1002.14
Precautions
P261-P264-P270-P271-P280-P302+P352-P304+P340-P305+P351+P338-P330-P362+P364-P403+P233-P405-P501
References & Citations
[1]Beck A, et al. Strategies and challenges for the next generation of antibody-drug conjugates. Nat Rev Drug Discov. 2017 May;16 (5) :315-337.
Shipping Conditions
Room temperature
Scientific Category
ADC Related
Clinical Information
No Development Reported
Isoform
Cleavable Linker
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