LeuRS-IN-1 (hydrochloride)
Product Specifications
UNSPSC Description
LeuRS-IN-1 hydrochloride is a potent, orally active M. tuberculosis leucyl-tRNA synthetase (M.tb LeuRS) inhibitor. LeuRS-IN-1 hydrochloride has IC50 and Kd values of 0.06 μM, 0.075 μM for M.tb LeuRS, respectively[1]. LeuRS-IN-1 hydrochloride inhibits human cytoplasmic LeuRS (IC50=38.8 μM), and HepG2 protein synthesis (EC50=19.6 μM)[2].
Target Antigen
Bacterial
Type
Reference compound
Related Pathways
Anti-infection
Field of Research
Infection
Assay Protocol
https://www.medchemexpress.com/leurs-in-1-hydrochloride.html
Solubility
10 mM in DMSO
Smiles
CCOC1=C2C([C@H](OB2O)CN)=C(C=C1)Cl.Cl
Molecular Weight
277.94
References & Citations
[1]Palencia A, et al. Discovery of Novel Oral Protein Synthesis Inhibitors of Mycobacterium tuberculosis That Target Leucyl-tRNA Synthetase. <i>Antimicrob Agents Chemother</i>. 2016;60(10):6271-6280. Published 2016 Sep 23.|[2]Li X, et al. Discovery of a Potent and Specific M. tuberculosis Leucyl-tRNA Synthetase Inhibitor: (S)-3-(Aminomethyl)-4-chloro-7-(2-hydroxyethoxy)benzo[c][1,2]oxaborol-1(3H)-ol (GSK656). J Med Chem. 2017 Oct 12;60(19):8011-8026.
Shipping Conditions
Room temperature
Product Datasheet
http://file.medchemexpress.com/batch_PDF/HY-139987A/LeuRS-IN-1-hydrochloride-DataSheet-MedChemExpress.pdf
Product MSDS
http://file.medchemexpress.com/batch_PDF/HY-139987A/
Clinical Information
No Development Reported
CAS Number
1364683-67-9
Curated Selection
Explore Other Products
Discover premium biology products from our extensive collection of 20M+ items
![Rabbit Polyclonal RBM34 Antibody [mFluor Violet 500 SE]](https://cdn.genprice.uk/genprice/genprice5.png)
