Telmisartan-d7

Telmisartan-d7 (BIBR 277-d7) is a deuterium labeled Telmisartan (HY-13955) . Telmisartan is a potent, long lasting antagonist of angiotensin II type 1 receptor (AT1), selectively inhibiting the binding of 125I-AngII to AT1 receptors with IC50 of 9.2 nM.

Product Specifications

CAS Number

[1794754-60-1]

Product Name Alternative

BIBR 277-d7

UNSPSC

12352005

Hazard Statement

H302, H315, H319, H335

Target

Angiotensin Receptor; Autophagy; Isotope-Labeled Compounds

Type

Isotope-Labeled Compounds

Related Pathways

Autophagy; GPCR/G Protein; Others

Applications

Neuroscience-Neuromodulation

Field of Research

Cardiovascular Disease

Purity

99.57

Solubility

10 mM in DMSO

Smiles

CCCC(N(C1=CC(C2=NC3=CC=CC=C3N2C([2H])([2H])[2H])=C4)CC5=C([2H])C([2H])=C(C6=C(C=CC=C6)C(O)=O)C([2H])=C5[2H])=NC1=C4C

Molecular Formula

C33H23D7N4O2

Molecular Weight

521.66

Precautions

H302, H315, H319, H335

References & Citations

[1]Russak EM, et al. Impact of Deuterium Substitution on the Pharmacokinetics of Pharmaceuticals. Ann Pharmacother. 2019 Feb;53 (2) :211-246.|[2]Maillard MP, et al. In vitro and in vivo characterization of the activity of telmisartan: an insurmountable angiotensin II receptor antagonist. J Pharmacol Exp Ther. 2002 Sep;302 (3) :1089-95.|[3]Xuan H, et al. Inhibition or deletion of angiotensin II type 1 receptor suppresses elastase-induced experimental abdominal aortic aneurysms. J Vasc Surg. 2017 Apr 20. pii: S0741-5214 (17) 30100-3.|[4]Torika N, et al. Intranasal telmisartan ameliorates brain pathology in five familial Alzheimer's disease mice. Brain Behav Immun. 2017 Apr 3.|[5]Aswar U, et al. Telmisartan attenuates diabetes induced depression in rats. Pharmacol Rep. 2017 Apr;69 (2) :358-364.|[6]Fujihara S, et al. The angiotensin II type 1 receptor antagonist telmisartan inhibits cell proliferation and tumor growth of esophageal adenocarcinoma via the AMPKα/mTOR pathway in vitro and in vivo. Oncotarget. 2017 Jan 31;8 (5) :8536-8549.