Thalidomide-5-PEG2-Cl
Thalidomide-5-PEG2-Cl is the Thalidomide-based cereblon ligand used in the recruitment of CRBN protein. Thalidomide-5-PEG2-Cl can be connected to the ligand for protein by a linker to form PROTACs[1].
Product Specifications
CAS Number
[2230956-57-5]
UNSPSC
12352005
Hazard Statement
H302, H315, H319, H335
Target
Apoptosis; Autophagy; E3 Ligase Ligand-Linker Conjugates
Type
Reference compound
Related Pathways
Apoptosis; Autophagy; PROTAC
Applications
Cancer-programmed cell death
Field of Research
Cancer
Assay Protocol
https://www.medchemexpress.com/thalidomide-5-peg2-cl.html
Purity
96.57
Solubility
10 mM in DMSO
Smiles
O=C1NC(C(CC1)N2C(C3=CC=C(C=C3C2=O)OCCOCCCl)=O)=O
Molecular Formula
C17H17ClN2O6
Molecular Weight
380.78
Precautions
H302, H315, H319, H335
References & Citations
[1]Nalawansha DA, et al. PROTACs: An Emerging Therapeutic Modality in Precision Medicine. Cell Chem Biol. 2020;27 (8) :998-994.
Shipping Conditions
Room Temperature
Storage Conditions
-20°C, 3 years; 4°C, 2 years (Powder)
Scientific Category
Reference compound1
Clinical Information
No Development Reported
Isoform
Cereblon
Available Sizes
Explore Other Products
Discover premium biology products from our extensive collection of 20M+ items
