PD0166285 (dihydrochloride)

PD0166285 dihydrochloride, a substrate of P-gp, is a WEE1 inhibitor and a weak Myt1 inhibitor with IC50 values of 24 and 72 nM, respectively. PD0166285 dihydrochloride exhibits an IC50 of 3.433 μM for Chk1[1].

Product Specifications

CAS Number

[212391-63-4]

UNSPSC

12352005

Target

Apoptosis; Wee1

Type

Reference compound

Related Pathways

Apoptosis; Cell Cycle/DNA Damage

Applications

Cancer-Kinase/protease

Field of Research

Cancer

Assay Protocol

https://www.medchemexpress.com/pd0166285-dihydrochloride.html

Solubility

10 mM in DMSO

Smiles

O=C1N(C)C2=NC(NC3=CC=C(OCCN(CC)CC)C=C3)=NC=C2C=C1C4=C(Cl)C=CC=C4Cl.[H]Cl.[H]Cl

Molecular Formula

C26H29Cl4N5O2

Molecular Weight

585.35

References & Citations

[1]Wang Y, et al. Radiosensitization of p53 mutant cells by PD0166285, a novel G (2) checkpoint abrogator. Cancer Res. 2001 Nov 15;61 (22) :8211-7.|[2]Mark C de Gooijer, et al. ATP-binding cassette transporters limit the brain penetration of Wee1 inhibitors. Invest New Drugs. 2018 Jun;36 (3) :380-387.