Dephospho-CoA

Dephospho-CoA is a key intermediate in the biosynthesis of coenzyme A (CoA), which is catalyzed by GTP-dependent dephospho-CoA kinase (DPCK) to generate CoA. Dephospho-CoA completes the final synthesis step of CoA through phosphorylation reaction and participates in energy metabolism and cell signaling. Dephospho-CoA can be used in research including cancer (such as regulating cell proliferation) and metabolic diseases (such as mitochondrial dysfunction) [1][2].

Product Specifications

CAS Number

[3633-59-8]

UNSPSC

12352005

Target

Endogenous Metabolite

Type

Natural Products

Related Pathways

Metabolic Enzyme/Protease

Applications

Metabolism-protein/nucleotide metabolism

Field of Research

Cancer; Metabolic Disease

Assay Protocol

https://www.medchemexpress.com/dephospho-coa.html

Purity

96.00

Solubility

H2O : 50 mg/mL (ultrasonic; warming)

Smiles

O[C@H]([C@@H]1O)[C@](O[C@@H]1CO[P](O[P](OCC(C)(C)[C@@H](O)C(NCCC(NCCS)=O)=O)(O)=O)(O)=O)([H])N2C3=NC=NC(N)=C3N=C2

Molecular Formula

C21H35N7O13P2S

Molecular Weight

687.55

References & Citations

[1]Gudkova D, et al. EDC4 interacts with and regulates the dephospho-CoA kinase activity of CoA synthase. FEBS Lett. 2012 Oct 19;586 (20) :3590-5.|[2]Shimosaka T, et al. Identification of Dephospho-Coenzyme A (Dephospho-CoA) Kinase in Thermococcus kodakarensis and Elucidation of the Entire CoA Biosynthesis Pathway in Archaea. mBio. 2019 Jul 23;10 (4) :e01146-19.