Ulotaront
SEP-363856 (SEP-856), an orally active TAAR1 and 5-HT1A agonist and CNS active psychotropic agent with a unique, non-D2/5-HT2A mechanism of action, exerts its antipsychotic-like effects. SEP-363856 (SEP-856) has the potential for the study of schizophrenia[1].
Product Specifications
CAS Number
[1310426-33-5]
Product Name Alternative
SEP-363856; SEP-856
UNSPSC
12352005
Target
5-HT Receptor
Type
Reference compound
Related Pathways
GPCR/G Protein; Neuronal Signaling
Applications
Neuroscience-Neuromodulation
Field of Research
Neurological Disease
Assay Protocol
https://www.medchemexpress.com/sep-363856.html
Solubility
10 mM in DMSO
Smiles
CNC[C@H]1C2=C(C=CS2)CCO1
Molecular Formula
C9H13NOS
Molecular Weight
183.27
References & Citations
[1]Dedic N, et al. SEP-363856, a Novel Psychotropic Agent with a Unique, Non-D2 Receptor Mechanism of Action. J Pharmacol Exp Ther. 2019 Oct;371 (1) :1-14.
Shipping Conditions
Room temperature
Scientific Category
Reference compound1
Clinical Information
Phase 3
Isoform
5-HT1 Receptor; mLAG-3; MUC3; α-1 microglobulin
Citation 01
Front Pharmacol. 2023 Apr 21:14:1161964.|J Med Chem. 2025 Apr 10;68 (7) :7082-7105.|Nature. 2023 Dec;624 (7992) :672-681.|Adv Sci (Weinh) . 2025 Oct 24:e02079.|Cell. 2023 Nov 22;186 (24) :5347-5362.e24.|Drug Dev Res. 2024 Jun;85 (4) :e22225.|Mol Pharmacol. 2025 Jul 28;107 (9) :100064.|Nature. 2024 Jun;630 (8015) :237-246.|Synapse. 2025 Mar;79 (2) :e70011.|World J Biol Psychiatry. 2024 Nov 29:1-18.
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