NAS-181
NAS-181 is a potent and selective rat 5-hydroxytryptamine1B (r5-HT1B) antagonist with an Ki value of 47 nM. NAS-181 increases the 5-HTP accumulation in rat brain regions[1].
Product Specifications
CAS Number
[205242-62-2]
UNSPSC
12352005
Target
5-HT Receptor
Type
Reference compound
Related Pathways
GPCR/G Protein; Neuronal Signaling
Applications
Neuroscience-Neuromodulation
Field of Research
Neurological Disease
Assay Protocol
https://www.medchemexpress.com/nas-181.html
Solubility
10 mM in DMSO
Smiles
CS(=O)(O)=O.[C@H]1(COC2=C3C(C=C(CN4CCOCC4)CO3)=CC=C2)CNCCO1
Molecular Formula
C20H30N2O7S
Molecular Weight
442.53
References & Citations
[1]Berg S, et al. (R) - (+) -2-[[[3- (Morpholinomethyl) -2H-chromen-8-yl]oxy]methyl] morpholine methanesulfonate: a new selective rat 5-hydroxytryptamine1B receptor antagonist. J Med Chem. 1998 May 21;41 (11) :1934-42.
Shipping Conditions
Room temperature
Scientific Category
Reference compound1
Clinical Information
No Development Reported
Isoform
5-HT1 Receptor
Citation 01
BioRxiv. 2025 August 23.|Nat Neurosci. 2022 Dec;25 (12) :1651-1663.|Transl Neurodegener. 2024 Jul 24;13 (1) :34.
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