LY393615

LY393615 (NCC1048) is a novel neuronal Ca2+ (calcium channel) and Na + channel (sodium channel) blocker with IC50s of 1.9 μΜ and 5.2 μΜ for α1A and α1B calcium channel subunits. LY393615 has good brain penetration and neuroprotective effects in models of in cerebral ischemia that can be used for neurological disease research[1].

Product Specifications

CAS Number

[325819-97-4]

Product Name Alternative

NCC1048

UNSPSC

12352005

Target

Calcium Channel; Sodium Channel

Type

Reference compound

Related Pathways

Membrane Transporter/Ion Channel; Neuronal Signaling

Applications

Neuroscience-Neuromodulation

Field of Research

Neurological Disease

Assay Protocol

https://www.medchemexpress.com/ly393615.html

Solubility

10 mM in DMSO

Smiles

FC1=CC=C(C2(C3=CC=C(F)C=C3)CCC(CNCCCC)O2)C=C1.[H]Cl

Molecular Formula

C21H26ClF2NO

Molecular Weight

381.89

References & Citations

[1]O'Neill MJ, et.al. LY393615, a novel neuronal Ca (2+) and Na (+) channel blocker with neuroprotective effects in models of in vitro and in vivo cerebral ischemia. Brain Res. 2001 Jan 5;888 (1) :138-149.