(±) -LY367385

(±) -LY367385 is the racemate of LY367385. LY367385 is a highly potent and selective mGluR1a antagonist. LY367385 has an IC50 of 8.8 μM for inhibits of quisqualate-induced phosphoinositide (PI) hydrolysis, compared with > 100 μM for mGlu5a[1][2].

Product Specifications

CAS Number

[198419-90-8]

UNSPSC

12352005

Hazard Statement

H302-H312-H332

Target

MGluR

Type

Reference compound

Related Pathways

GPCR/G Protein; Neuronal Signaling

Applications

Neuroscience-Neuromodulation

Field of Research

Neurological Disease

Assay Protocol

https://www.medchemexpress.com/racemic-ly367385.html

Purity

98.0

Solubility

H2O : 5.56 mg/mL (ultrasonic; warming; heat to 60°C)

Smiles

O=C(O)C(N)C1=CC=C(C(O)=O)C=C1C

Molecular Formula

C10H11NO4

Molecular Weight

209.20

Precautions

P261-P264-P270-P271-P280-P302+P352-P304+P340-P330-P363-P501

References & Citations

[1]Clark et al. (+) -2-Methyl-4-carboxyphenylglycine (LY 367385) selectively antagonises metabotropic glutamate mGluR1 receptors. Bioorg.Med.Chem.Lett. November 1997, 7 (21) : 2777-2780.|[2]V Bruno, et al. Neuroprotective activity of the potent and selective mGlu1a metabotropic glutamate receptor antagonist, (+) -2-methyl-4 carboxyphenylglycine (LY367385) : comparison with LY357366, a broader spectrum antagonist with equal affinity for mGlu1a and mGlu5 receptors. europharmacology. 1999 Feb;38 (2) :199-207.