Ganfeborole

Ganfeborole (GSK656 free base) is a potent, selective and orally active inhibitor of M. tuberculosis leucyl-tRNA synthetase, with an IC50 of 0.20 μM. Ganfeborole can be used for the research of tuberculosis[1].

Product Specifications

CAS Number

[2131798-12-2]

Product Name Alternative

GSK656 (free base) ; GSK3036656 (free base) ; GSK070 (free base)

UNSPSC

12352005

Hazard Statement

H302-H315-H319-H335

Target

Bacterial

Type

Reference compound

Related Pathways

Anti-infection

Applications

COVID-19-immunoregulation

Field of Research

Infection

Assay Protocol

https://www.medchemexpress.com/ganfeborole.html

Solubility

10 mM in DMSO

Smiles

OB1O[C@H](CN)C2=C(Cl)C=CC(OCCO)=C21

Molecular Formula

C10H13BClNO4

Molecular Weight

257.48

Precautions

P261-P264-P270-P271-P280-P302+P352-P304+P340-P305+P351+P338-P330-P362+P364-P403+P233-P405-P501

References & Citations

[1]Li X, et, al. Discovery of a Potent and Specific M. tuberculosis Leucyl-tRNA Synthetase Inhibitor: (S) -3- (Aminomethyl) -4-chloro-7- (2-hydroxyethoxy) benzo[c][1,2]oxaborol-1 (3H) -ol (GSK656) . J Med Chem. 2017 Oct 12;60 (19) :8011-8026.