cGMP-HTL
Product Specifications
UNSPSC Description
cGMP-HTL contains a HT-ligand, a linker and the Cys-S-cGMP (autophagy tag). cGMP-HTL increases the K63-linked ubiquitination of mitochondria. AUTAC (autophagy-targeting chimera) is a novel targeted-clearance strategy that contains a degradation tag (guanine derivatives) and a warhead to provide target specificity[1].
Target Antigen
Autophagy
Type
Reference compound
Related Pathways
Autophagy
Applications
Cancer-programmed cell death
Field of Research
Cancer
Assay Protocol
https://www.medchemexpress.com/cgmp-htl.html
Solubility
10 mM in DMSO
Smiles
NC(N1)=NC2=C(N=C(SC[C@H](NC(C)=O)C(NCCOCCOCCOCCOCCOCCCCCCCl)=O)N2[C@H]3[C@H](O)[C@H](OP4(O)=O)[C@@H](CO4)O3)C1=O
Molecular Weight
844.27
References & Citations
[1]Daiki Takahashi, et al. AUTACs: Cargo-Specific Degraders Using Selective Autophagy. Mol Cell. 2019 Dec 5;76(5):797-810.e10.
Shipping Conditions
Room temperature
Product Datasheet
http://file.medchemexpress.com/batch_PDF/HY-133869/cGMP-HTL-DataSheet-MedChemExpress.pdf
Product MSDS
http://file.medchemexpress.com/batch_PDF/HY-133869/
Clinical Information
No Development Reported
Curated Selection
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