Venetoclax N-oxide
Product Specifications
UNSPSC Description
Venetoclax N-oxide is an impurity of Venetoclax. Venetoclax (ABT-199; GDC-0199) is a highly potent, selective and orally bioavailable Bcl-2 inhibitor with a Ki of less than 0.01 nM[1].
Target Antigen
Drug Metabolite
Type
Reference compound
Related Pathways
Metabolic Enzyme/Protease
Field of Research
Others
Assay Protocol
https://www.medchemexpress.com/venetoclax-n-oxide.html
Solubility
10 mM in DMSO
Smiles
O=C(NS(=O)(C1=CC=C(NCC2CCOCC2)C([N+]([O-])=O)=C1)=O)C3=CC=C(N4CC[N+](CC5=C(C6=CC=C(Cl)C=C6)CC(C)(C)CC5)([O-])CC4)C=C3OC7=CN=C(NC=C8)C8=C7
Molecular Weight
884.44
References & Citations
[1]Souers AJ, et al. ABT-199, a potent and selective BCL-2 inhibitor, achieves antitumor activity while sparing platelets. Nat Med. 2013 Feb;19(2):202-8.
Shipping Conditions
Room temperature
Product Datasheet
http://file.medchemexpress.com/batch_PDF/HY-133772/Venetoclax-N-oxide-DataSheet-MedChemExpress.pdf
Product MSDS
http://file.medchemexpress.com/batch_PDF/HY-133772/
Clinical Information
No Development Reported
CAS Number
2469279-00-1
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