Irsenontrine (maleate)
Product Specifications
UNSPSC Description
Irsenontrine (E2027) maleate is an orally active and selective phosphodiesterase 9 (PDE9) inhibitor. Irsenontrine maleate can be used for the research of neurological diseases[1][2].
Target Antigen
Phosphodiesterase (PDE)
Type
Reference compound
Related Pathways
Metabolic Enzyme/Protease
Field of Research
Neurological Disease
Assay Protocol
https://www.medchemexpress.com/irsenontrine-maleate.html
Solubility
10 mM in DMSO
Smiles
O=C1NC2=C(C=CC(C3=C(C)C(OC)=NC=C3C)=C2)C4=C1C=NN4[C@@H]5COCC5.O=C(O)/C=C\C(O)=O
Molecular Weight
506.51
References & Citations
[1]Miyamoto, et al. Dementia therapeutic agent combining pyrazoloquinoline derivative and memantine. WO2018221550 A1|[2]Hershey LA, et al. Pharmacological Management of Dementia with Lewy Bodies. Drugs Aging. 2019;36(4):309-319.|[3]Eisai to present latest research on Alzheimer’s disease / dementia pipeline at the 14th international conference on Alzheimer’s & Parkinson’s diseases
Shipping Conditions
Room temperature
Product Datasheet
http://file.medchemexpress.com/batch_PDF/HY-132821A/Irsenontrine-maleate-DataSheet-MedChemExpress.pdf
Product MSDS
http://file.medchemexpress.com/batch_PDF/HY-132821A/
Clinical Information
Phase 2
CAS Number
1630083-70-3
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