RJW100
Product Specifications
UNSPSC Description
RJW100 is a potent liver receptor homolog 1 (LRH-1, NR5A2) and steroidogenic factor-1 (SF-1, NR5A1) agonist with pEC50s of 6.6 and 7.5, respectively[1]. RJW100 also causes strong activation of the miR-200c (miRNA-200c, microRNA-200c) promoter[2].
Target Antigen
MicroRNA
Type
Reference compound
Related Pathways
Epigenetics
Applications
Metabolism-sugar/lipid metabolism
Field of Research
Cancer; Endocrinology
Assay Protocol
https://www.medchemexpress.com/rjw100.html
Purity
99.93
Solubility
10 mM in DMSO
Smiles
O[C@@H]1CC[C@@]2(C(C3=CC=CC=C3)=C)C(C4=CC=CC=C4)=C(CCCCCC)C[C@@]12[H]
Molecular Weight
386.58
References & Citations
[1]Richard J Whitby, et al. Small molecule agonists of the orphan nuclear receptors steroidogenic factor-1 (SF-1, NR5A1) and liver receptor homologue-1 (LRH-1, NR5A2). J Med Chem. 2011 Apr 14;54(7):2266-81.|[2]Yuxia Zhang, et al. Regulation of miR-200c by nuclear receptors PPARα, LRH-1 and SHP. Biochem Biophys Res Commun. 2011 Dec 9;416(1-2):135-9.
Shipping Conditions
Room Temperature
Storage Conditions
-20°C, 3 years; 4°C, 2 years (Powder)
Product Datasheet
http://file.medchemexpress.com/batch_PDF/HY-131445/RJW100-DataSheet-MedChemExpress.pdf
Product MSDS
http://file.medchemexpress.com/batch_PDF/HY-131445/RJW100-SDS-MedChemExpress.pdf
Clinical Information
No Development Reported
CAS Number
1276664-20-0
Curated Selection
Explore Other Products
Discover premium biology products from our extensive collection of 20M+ items
ARP39662_P050-FITC 100 µL
ADPGK Antibody - middle region: FITC (ARP39662_P050-FITC)
Ask
View Details 
MPC0362K Each
Magic™ Membrane Protein Human KCNE4 (Potassium voltage-gated channel subfamily E regulatory subunit 4) Full Length
Ask
View Details