DBCO-NH-(CH2)4COOH
Product Specifications
UNSPSC Description
DBCO-NH-(CH2)4COOH is an alkyl chain-based PROTAC linker that can be used in the synthesis of PROTACs[1]. DBCO-NH-(CH2)4COOH is a click chemistry reagent, it contains a DBCO group that can undergo strain-promoted alkyne-azide cycloaddition (SPAAC) with molecules containing Azide groups.
Target Antigen
PROTAC Linkers
Type
Reference compound
Related Pathways
PROTAC
Applications
Cancer-programmed cell death
Field of Research
Cancer
Assay Protocol
https://www.medchemexpress.com/dbco-nh-ch2-4cooh.html
Solubility
10 mM in DMSO
Smiles
OC(CCCCC(NCCC(N1CC2=C(C#CC3=C1C=CC=C3)C=CC=C2)=O)=O)=O
Molecular Weight
404.46
References & Citations
[1]An S, et al. Small-molecule PROTACs: An emerging and promising approach for the development of targeted therapy drugs. EBioMedicine. 2018 Oct;36:553-562
Shipping Conditions
Room temperature
Product Datasheet
http://file.medchemexpress.com/batch_PDF/HY-130912/DBCO-NH-CH2-4COOH-DataSheet-MedChemExpress.pdf
Product MSDS
http://file.medchemexpress.com/batch_PDF/HY-130912/
Clinical Information
No Development Reported
CAS Number
2375193-74-9
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