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N3-PEG8-CH2COOH

N3-PEG8-CH2COOH is a PEG-based PROTAC linker can be used in the synthesis of PROTACs[1]. N3-PEG8-CH2COOH is a click chemistry reagent, it contains an Azide group and can undergo copper-catalyzed azide-alkyne cycloaddition reaction (CuAAc) with molecules containing Alkyne groups. It can also undergo strain-promoted alkyne-azide cycloaddition (SPAAC) reactions with molecules containing DBCO or BCN groups.

Product Specifications

CAS Number

[1343472-07-0]

UNSPSC

12352211

Target

PROTAC Linkers

Type

Reference compound

Related Pathways

PROTAC

Applications

Cancer-programmed cell death

Field of Research

Cancer

Assay Protocol

https://www.medchemexpress.com/n3-peg8-ch2cooh.html

Solubility

10 mM in DMSO

Smiles

O=C(O)COCCOCCOCCOCCOCCOCCOCCOCCN=[N+]=[N-]

Molecular Formula

C18H35N3O10

Molecular Weight

453.48

References & Citations

[1] Steinmetz NF, et al. Intravital imaging of human prostate cancer using viral nanoparticles targeted to gastrin-releasing Peptide receptors. Small. 2011 Jun 20;7 (12) :1664-72.

Shipping Conditions

Room temperature

Scientific Category

Reference compound1

Clinical Information

No Development Reported

Isoform

PEG Linkers

Available Sizes

Curated Selection

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