Bafilomycin C1

Bafilomycin C1 is a macrolide antibiotic isolated from Streptomyces sp. Bafilomycin C1 is a potent, specific and reversible inhibitor of vacuolar-type H+-ATPases (V-ATPases) . Bafilomycin C1 inhibits growth of gram-positive bacteria and fungi[2]. Bafilomycin C1 induces cell apoptosis and can be used for the study of hepatocellular carcinoma (HCC) [2].

Product Specifications

CAS Number

[88979-61-7]

UNSPSC

12352005

Hazard Statement

H301, H312, H330, H410

Target

Antibiotic; Apoptosis; Bacterial; Fungal; Na+/K+ ATPase

Type

Natural Products

Related Pathways

Anti-infection; Apoptosis; Membrane Transporter/Ion Channel

Applications

COVID-19-immunoregulation

Field of Research

Cancer; Infection

Assay Protocol

https://www.medchemexpress.com/bafilomycin-c1.html

Purity

99.9

Solubility

DMSO : 5 mg/mL (ultrasonic; warming)

Smiles

C[C@H]([C@@](C[C@H]([C@@H]1C)OC(/C=C/C(O)=O)=O)(O[C@@H]1C(C)C)O)[C@H](O)[C@@H]([C@](OC(/C(OC)=C/C(C)=C/[C@H]2C)=O)([H])[C@H](/C=C/C=C(C[C@@H]([C@@H]2O)C)\C)OC)C

Molecular Formula

C39H60O12

Molecular Weight

720.89

Precautions

H301, H312, H330, H410

References & Citations

[1]E J Bowman, et al. Bafilomycins: A Class of Inhibitors of Membrane ATPases From Microorganisms, Animal Cells, and Plant Cells. Proc Natl Acad Sci U S A. 1988 Nov;85 (21) :7972-6.|[2]Xiaoxiao Gao, et al.Bafilomycin C1 Induces G0/G1 Cell-Cycle Arrest and Mitochondrial-Mediated Apoptosis in Human Hepatocellular Cancer SMMC7721 Cells. J Antibiot (Tokyo) . 2018 Sep;71 (9) :808-817.