Integrin-IN-2
Integrin-IN-2 (compound 39) is an orally bioavailable pan αv integrin inhibitor. Integrin-IN-2 can increases the αvβ6, αvβ3, αvβ5 and αvβ8 binding affinities with pIC50 values of 7.8, 8.4, 8.4 and 7.4, respectively[1].
Product Specifications
CAS Number
[2378617-67-3]
UNSPSC
12352005
Target
Integrin
Type
Reference compound
Related Pathways
Cytoskeleton
Applications
Cancer-programmed cell death
Field of Research
Cancer
Assay Protocol
https://www.medchemexpress.com/integrin-in-2.html
Purity
95.71
Solubility
10 mM in DMSO
Smiles
O=C(O)CC(C1=CC=CC(C2CC2)=C1)NC3=NC=C(OCCC4=NC5=C(CCCN5)C=C4)C=C3
Molecular Formula
C27H30N4O3
Molecular Weight
458.55
References & Citations
[1]Anderson NA, et al. Discovery of an Orally Bioavailable Pan αv Integrin Inhibitor for Idiopathic Pulmonary Fibrosis. J Med Chem. 2019 Oct 10;62 (19) :8796-8808.
Shipping Conditions
Room Temperature
Storage Conditions
4°C (Powder, protect from light)
Scientific Category
Reference compound1
Clinical Information
No Development Reported
Curated Selection
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