CLH304a
CLH304a (compound 14) is a specific and noncompetitive GABAB receptor negative allosteric modulator (NAM) . CLH304a decreases GABA-induced IP3 production with an IC50 of 37.9 μM. CLH304a has no effect on other GPCR Class C members such as mGluR1, mGluR2, and mGluR5. CLH304a acts on the heptahelical domain of GB2 subunits and non-competitively inhibits the effect of agonists with inverse agonist properties. CLH304a inhibits Baclofen (HY-B0007) -induced ERK1/2 phosphorylation in HEK293 cells overexpressing GABAB receptor[1][2].
Product Specifications
CAS Number
[1611483-29-4]
Product Name Alternative
(E) -GABAB receptor antagonist 1
UNSPSC
12352005
Target
ERK; GABA Receptor
Type
Reference compound
Related Pathways
MAPK/ERK Pathway; Membrane Transporter/Ion Channel; Neuronal Signaling; Stem Cell/Wnt
Applications
Neuroscience-Neuromodulation
Field of Research
Neurological Disease
Assay Protocol
https://www.medchemexpress.com/clh304a.html
Purity
99.64
Solubility
DMSO : ≥ 100 mg/mL
Smiles
O=C(C(/C=C/C1=CC(C(C)(C)C)=C(C(C(C)(C)C)=C1)O)=O)O
Molecular Formula
C18H24O4
Molecular Weight
304.38
References & Citations
Shipping Conditions
Blue Ice
Storage Conditions
-20°C, 3 years (Powder)
Scientific Category
Reference compound1
Clinical Information
No Development Reported
Available Sizes
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