AMG-8718
Product Specifications
UNSPSC Description
AMG-8718 is a potent, selective and orally active BACE1 inhibitor with IC50 values of 0.0007, 0.005 μM for BACE1 and BACE2, respectively. AMG-8718 significantly decreases Aβ40 levels in the CSF and brain[1].
Target Antigen
Beta-secretase
Type
Reference compound
Related Pathways
Neuronal Signaling
Applications
Neuroscience-Neurodegeneration
Field of Research
Neurological Disease
Assay Protocol
https://www.medchemexpress.com/amg-8718.html
Solubility
10 mM in DMSO
Smiles
NC(OC1)=N[C@]1(C2=CC(C#CC3(C)COC3)=CN=C2O4)C5=C4C=CC(C6=CC=CN=C6F)=C5
Molecular Weight
442.44
References & Citations
[1]Dineen TA,et al. Inhibitors of β-site amyloid precursor protein cleaving enzyme (BACE1): identification of (S)-7-(2-fluoropyridin-3-yl)-3-((3-methyloxetan-3-yl)ethynyl)-5'H-spiro[chromeno[2,3-b]pyridine-5,4'-oxazol]-2'-amine (AMG-8718). J Med Chem. 2014 Dec 11;57(23):9811-31.
Shipping Conditions
Room temperature
Product Datasheet
http://file.medchemexpress.com/batch_PDF/HY-12938/AMG-8718-DataSheet-MedChemExpress.pdf
Product MSDS
http://file.medchemexpress.com/batch_PDF/HY-12938/
Clinical Information
No Development Reported
CAS Number
1215868-94-2
Curated Selection
Explore Other Products
Discover premium biology products from our extensive collection of 20M+ items
MBS9318899-01 48 Well
Human Putative uncharacterized protein C1orf150, C1orf150 ELISA Kit
Ask
View Details 
MBS9318899-02 96 Well
Human Putative uncharacterized protein C1orf150, C1orf150 ELISA Kit
Ask
View Details MBS9318899-03 5x 96 Well
Human Putative uncharacterized protein C1orf150, C1orf150 ELISA Kit
Ask
View Details MBS9318899-04 10x 96 Well
Human Putative uncharacterized protein C1orf150, C1orf150 ELISA Kit
Ask
View Details