AMG-8718

AMG-8718 is a potent, selective and orally active BACE1 inhibitor with IC50 values of 0.0007, 0.005 μM for BACE1 and BACE2, respectively. AMG-8718 significantly decreases Aβ40 levels in the CSF and brain[1].

Product Specifications

CAS Number

[1215868-94-2]

UNSPSC

12352005

Target

Beta-secretase

Type

Reference compound

Related Pathways

Neuronal Signaling

Applications

Neuroscience-Neurodegeneration

Field of Research

Neurological Disease

Assay Protocol

https://www.medchemexpress.com/amg-8718.html

Solubility

10 mM in DMSO

Smiles

NC(OC1)=N[C@]1(C2=CC(C#CC3(C)COC3)=CN=C2O4)C5=C4C=CC(C6=CC=CN=C6F)=C5

Molecular Formula

C25H19FN4O3

Molecular Weight

442.44

References & Citations

[1]Dineen TA, et al. Inhibitors of β-site amyloid precursor protein cleaving enzyme (BACE1) : identification of (S) -7- (2-fluoropyridin-3-yl) -3- ((3-methyloxetan-3-yl) ethynyl) -5'H-spiro[chromeno[2,3-b]pyridine-5,4'-oxazol]-2'-amine (AMG-8718) . J Med Chem. 2014 Dec 11;57 (23) :9811-31.