Arborinine

Arborinine is a potent and orally activeLSD1 inhibitor. Arborinine increases the expression of H3K4me1/2, H3K9me1/2, E-cad protein and decreases the expression of UBE2O protein level. Arborinine induces cell cycle arrest at S phase. Arborinine shows antitumor activity [1][2].

Product Specifications

CAS Number

[5489-57-6]

UNSPSC

12352005

Target

Histone Demethylase

Type

Natural Products

Related Pathways

Epigenetics

Applications

Cancer-programmed cell death

Field of Research

Cancer

Assay Protocol

https://www.medchemexpress.com/arborinine.html

Purity

99.87

Solubility

DMSO : 25 mg/mL (ultrasonic)

Smiles

O=C1C2=C(C=CC=C2)N(C)C3=CC(OC)=C(OC)C(O)=C13

Molecular Formula

C16H15NO4

Molecular Weight

285.29

References & Citations

[1]Feng C, et al. Arborinine from Glycosmis parva leaf extract inhibits clear-cell renal cell carcinoma by inhibiting KDM1A/UBE2O signaling. Food Nutr Res. 2022 Sep 16;66.|[2]Chu Y, et al. Arborinine, a potential LSD1 inhibitor, inhibits epithelial-mesenchymal transition of SGC-7901 cells and adriamycin-resistant gastric cancer SGC-7901/ADR cells. Invest New Drugs. 2021 Jun;39 (3) :627-635.