Guanabenz

Guanabenz is an orally active α-2-adrenoceptor agonist. Guanabenz has antihypertensive effect and antiparasitic activity. Guanabenz interferes ER stress-signalling and has protective effects in cardiac myocytes. Guanabenz also is used for the research of high blood pressure[1][2][3].

Product Specifications

CAS Number

[5051-62-7]

UNSPSC

12352005

Hazard Statement

H302+H312+H332, H361

Target

Adrenergic Receptor; Parasite

Type

Reference compound

Related Pathways

Anti-infection; GPCR/G Protein; Neuronal Signaling

Applications

COVID-19-immunoregulation

Field of Research

Cardiovascular Disease; Cancer

Assay Protocol

https://www.medchemexpress.com/guanabenz.html

Concentration

10mM

Purity

99.85

Solubility

DMSO : 16.67 mg/mL (ultrasonic; warming; heat to 60°C)

Smiles

ClC1=C(/C=N/NC(N)=N)C(Cl)=CC=C1

Molecular Formula

C8H8Cl2N4

Molecular Weight

231.08

Precautions

H302+H312+H332, H361

References & Citations

[1]Christiane Neuber, et al. Guanabenz interferes with ER stress and exerts protective effects in cardiac myocytes. PLoS One. 2014 Jun 3;9 (6) :e98893.|[2]Jennifer Martynowicz, et al. Guanabenz Reverses a Key Behavioral Change Caused by Latent Toxoplasmosis in Mice by Reducing Neuroinflammation. mBio. 2019 Apr 30;10 (2) :e00381-19.|[3]T Baum, et al. Studies on the centrally mediated hypotensive activity of guanabenz. Eur J Pharmacol. 1976 May;37 (1) :31-44.