Chrysomycin A

Chrysomycin A (Chr-A), an antibiotic, can be obtained from Streptomyces. Chrysomycin A exhibits antitumor and anti-tuberculous and MRSA activities. As for glioblastoma, Chrysomycin A inhibits the proliferation, migration, and invasion of cancer cells through the Akt/GSK-3β/β-catenin signaling pathway[1].

Product Specifications

CAS Number

[82196-88-1]

Product Name Alternative

Chr-A

UNSPSC

12352005

Hazard Statement

H302+H312-H319-H351

Target

Akt; Antibiotic; Bacterial; c-Myc; GSK-3; β-catenin

Type

Reference compound

Related Pathways

Anti-infection; Apoptosis; PI3K/Akt/mTOR; Stem Cell/Wnt

Applications

COVID-19-immunoregulation

Field of Research

Cancer; Infection

Assay Protocol

https://www.medchemexpress.com/chrysomycin-a.html

Purity

98.0

Solubility

10 mM in DMSO

Smiles

O=C1C2=CC(C=C)=CC(OC)=C2C3=CC(OC)=C4C(O)=CC=C([C@H]5[C@@H]([C@]([C@H]([C@@H](C)O5)O)(C)O)O)C4=C3O1

Molecular Formula

C28H28O9

Molecular Weight

508.52

Precautions

P264-P270-P280-P302+P352-P305+P351+P338-P330-P362+P364-P405-P501

References & Citations

[1]Liu DN, et al. Chrysomycin A Inhibits the Proliferation, Migration and Invasion of U251 and U87-MG Glioblastoma Cells to Exert Its Anti-Cancer Effects. Molecules. 2022 Sep 20;27 (19) :6148.