PAT-347
Product Specifications
UNSPSC Description
PAT-347 is an Autotaxin (ATX) inhibitor. ATX is a secretory enzyme that hydrolyzes lysophosphatidylcholine (LPC) and regulates lysophosphatidic acid (LPA) production in the blood[1][2].
Target Antigen
Phosphodiesterase (PDE)
Type
Reference compound
Related Pathways
Metabolic Enzyme/Protease
Applications
Metabolism-protein/nucleotide metabolism
Field of Research
Metabolic Disease
Assay Protocol
https://www.medchemexpress.com/pat-347.html
Solubility
10 mM in DMSO
Smiles
O=C(O)C1=CC=CC(SC2=C(C)N(CC(N3CC4(C5=C3C=CC=C5)CC4)=O)C6=C2C=CC(Cl)=C6F)=C1F
Molecular Weight
538.99
References & Citations
[1]Joncour A, et al. Discovery, structure–activity relationship, and binding mode of an imidazo [1, 2-a] pyridine series of autotaxin inhibitors[J]. Journal of Medicinal Chemistry, 2017, 60(17): 7371-7392. |[2]Chen Y, et al. Design, synthesis and anti-fibrosis evaluation of imidazo [1, 2–a] pyridine derivatives as potent ATX inhibitors[J]. Bioorganic & Medicinal Chemistry, 2021, 46: 116362.
Shipping Conditions
Room temperature
Product Datasheet
http://file.medchemexpress.com/batch_PDF/HY-126233/PAT-347-DataSheet-MedChemExpress.pdf
Product MSDS
http://file.medchemexpress.com/batch_PDF/HY-126233/
Clinical Information
No Development Reported
CAS Number
1689554-51-5
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