Venturicidin B

Venturicidin B (Aabomycin A2) is a macrolide antibiotic isolated from Streptomyces sp., used as an antifungal agent, a potent inhibitor of the mitochondrial F0-ATP synthase complex[1].

Product Specifications

CAS Number

[33538-72-6]

Product Name Alternative

Aabomycin A2

UNSPSC

12352005

Target

Antibiotic; ATP Synthase; Fungal

Type

Reference compound

Related Pathways

Anti-infection; Membrane Transporter/Ion Channel

Applications

COVID-19-immunoregulation

Field of Research

Infection

Assay Protocol

https://www.medchemexpress.com/venturicidin-b.html

Solubility

10 mM in DMSO

Smiles

O[C@@]12O[C@@](/C(C)=C/CCC[C@H](/C=C/[C@@H](C[C@H]([C@@](OC(C2)=O)([H])[C@H](C)C[C@@H](C)[C@H](O)[C@H](C)C(CC)=O)C)C)O[C@H]3C[C@H]([C@@H]([C@H](O3)C)O)O)([H])C(C)=CC1

Molecular Formula

C40H66O10

Molecular Weight

706.95

References & Citations

[1]Yakov M Milgrom, et al. Complex effects of macrolide venturicidins on bacterial F-ATPases likely contribute to their action as antibiotic adjuvants. Sci Rep. 2021 Jul 1;11 (1) :13631.