(S)-PNU-282987 (hydrochloride)
Product Specifications
UNSPSC Description
(S)-PNU-282987 hydrochloride is an isoform of PNU-282987 (HY-12560). PNU-282987 (free base) is a potent α7 nicotinic acetylcholine receptor (nAChR) agonist with an EC50 of 154 nM. PNU-282987 (free base) is also a functional antagonist of the 5-HT3 receptor with an IC50 of 4541 nM. PNU-282987 (free base) can be used for the research of central and peripheral nervous systems[1].
Target Antigen
5-HT Receptor; nAChR
Type
Reference compound
Related Pathways
GPCR/G Protein;Membrane Transporter/Ion Channel;Neuronal Signaling
Applications
Neuroscience-Neuromodulation
Field of Research
Neurological Disease
Assay Protocol
https://www.medchemexpress.com/s-pnu-282987-hydrochloride.html
Solubility
10 mM in DMSO
Smiles
O=C(C1=CC=C(Cl)C=C1)N[C@H]2C3CCN(CC3)C2.Cl
Molecular Weight
301.21
References & Citations
[1]Bodnar AL, Discovery and structure-activity relationship of quinuclidine benzamides as agonists of alpha7 nicotinic acetylcholine receptors. J Med Chem. 2005 Feb 24;48(4):905-8.
Shipping Conditions
Room temperature
Product Datasheet
http://file.medchemexpress.com/batch_PDF/HY-12560C/S-PNU-282987-hydrochloride-DataSheet-MedChemExpress.pdf
Product MSDS
http://file.medchemexpress.com/batch_PDF/HY-12560C/
Clinical Information
No Development Reported
CAS Number
128311-08-0
Curated Selection
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