(S) -PNU-282987 (hydrochloride)

(S) -PNU-282987 hydrochloride is an isoform of PNU-282987 (HY-12560) . PNU-282987 (free base) is a potent α7 nicotinic acetylcholine receptor (nAChR) agonist with an EC50 of 154 nM. PNU-282987 (free base) is also a functional antagonist of the 5-HT3 receptor with an IC50 of 4541 nM. PNU-282987 (free base) can be used for the research of central and peripheral nervous systems[1].

Product Specifications

CAS Number

[128311-08-0]

UNSPSC

12352005

Hazard Statement

H302-H315-H319-H335

Target

5-HT Receptor; nAChR

Type

Reference compound

Related Pathways

GPCR/G Protein; Membrane Transporter/Ion Channel; Neuronal Signaling

Applications

Neuroscience-Neuromodulation

Field of Research

Neurological Disease

Assay Protocol

https://www.medchemexpress.com/s-pnu-282987-hydrochloride.html

Solubility

10 mM in DMSO

Smiles

O=C(C1=CC=C(Cl)C=C1)N[C@H]2C3CCN(CC3)C2.Cl

Molecular Formula

C14H18Cl2N2O

Molecular Weight

301.21

Precautions

P261-P264-P270-P271-P280-P302+P352-P304+P340-P305+P351+P338-P330-P362+P364-P403+P233-P405-P501

References & Citations

[1]Bodnar AL, Discovery and structure-activity relationship of quinuclidine benzamides as agonists of alpha7 nicotinic acetylcholine receptors. J Med Chem. 2005 Feb 24;48 (4) :905-8.