Brevetoxin B

Brevetoxin B (Brevetoxin-2; PbTx-2) is a polyketide neurotoxin produced by Karenia species and other dinoflagellates. Brevetoxin B binds to site 5 on the alpha subunit of voltage-gated sodium channels (IC50=15 nM) on neurons at the neuromuscular junction, causing the channel to open irreversibly at potentials more negative than normal, discharging action potentials repetitively.

Product Specifications

CAS Number

[79580-28-2]

Product Name Alternative

Brevetoxin-2; PbTx-2

UNSPSC

12352005

Hazard Statement

H300+H310+H330

Target

Sodium Channel

Type

Natural Products

Related Pathways

Membrane Transporter/Ion Channel

Applications

Neuroscience-Neuromodulation

Field of Research

Neurological Disease

Assay Protocol

https://www.medchemexpress.com/brevetoxin-b.html

Purity

95.0

Solubility

10 mM in DMSO

Smiles

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