Trichodesmine

Trichodesmine is a dehydropyrrolizidine alkaloid. Trichodesmine can produces hepatotoxicty, pneumo- and neurotoxicity in vivo[1][2].

Product Specifications

CAS Number

[548-90-3]

UNSPSC

12352005

Hazard Statement

H300-H370

Target

Glutathione S-transferase

Type

Natural Products

Related Pathways

Metabolic Enzyme/Protease

Applications

Metabolism-protein/nucleotide metabolism

Field of Research

Metabolic Disease; Neurological Disease

Assay Protocol

https://www.medchemexpress.com/trichodesmine.html

Solubility

10 mM in DMSO

Smiles

O=C(O[C@]1([H])CCN2[C@]1([H])C(CO3)=CC2)[C@H](C(C)C)[C@@](C)(O)[C@@](C)(O)C3=O

Molecular Formula

C18H27NO6

Molecular Weight

353.41

Precautions

P260-P264-P270-P308+P311-P330-P405-P501

References & Citations

[1]Cooper RA, et, al. The relationship between reactivity of metabolites of pyrrolizidine alkaloids and extrahepatic toxicity. Proc West Pharmacol Soc. 1999;42:13-6.|[2]Pessoa CRM, et, al. Pulmonary and hepatic lesions caused by the dehydropyrrolizidine alkaloid-producing plants Crotalaria juncea and Crotalaria retusa in donkeys. Toxicon. 2013 Sep;71:113-20.