KY-02327
KY-02327, a metabolically stabilized KY-02061 analog, is a potent Dishevelled (Dvl) -CXXC5 interaction inhibitor. KY-02327 shows an activating effect on the Wnt/β-catenin pathway, resulting in promotion of osteoblast differentiation[1].
Product Specifications
CAS Number
[2093407-25-9]
UNSPSC
12352005
Hazard Statement
H302-H315-H319
Target
Wnt
Type
Reference compound
Related Pathways
Stem Cell/Wnt
Applications
Metabolism-protein/nucleotide metabolism
Field of Research
Metabolic Disease
Assay Protocol
https://www.medchemexpress.com/ky-02327.html
Purity
92.62
Solubility
DMSO : 100 mg/mL (ultrasonic)
Smiles
O=C(C(N1CC(NCCN2CCCCC2)=O)=CC3=C1C=CC(O)=C3)OCC
Molecular Formula
C20H27N3O4
Molecular Weight
373.45
Precautions
P264-P270-P280-P302+P352-P305+P351+P338-P330-P362+P364-P501
References & Citations
[1]Kim HY, et al. Small molecule inhibitors of the Dishevelled-CXXC5 interaction are new drug candidates for bone anabolic osteoporosis therapy. EMBO Mol Med. 2016;8 (4) :375-387.
Shipping Conditions
Room Temperature
Storage Conditions
-20°C, 3 years; 4°C, 2 years (Powder)
Scientific Category
Reference compound1
Clinical Information
No Development Reported
Curated Selection
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