EGFR-IN-99
Product Specifications
UNSPSC Description
EGFR-IN-99 (compound 1a) is a potent EGFR and HER2 Exon 20 insertion mutant inhibitor. EGFR-IN-99 has excellent antiproliferative activity against DFCI127 cells, with an EC50 of 11.5 nM. EGFR-IN-99 can be used for the research of non-small cell lung cancer (NSCLC)[1].
Target Antigen
EGFR
Type
Reference compound
Related Pathways
JAK/STAT Signaling;Protein Tyrosine Kinase/RTK
Applications
Cancer-Kinase/protease
Field of Research
Cancer
Assay Protocol
https://www.medchemexpress.com/egfr-in-99.html
Solubility
10 mM in DMSO
Smiles
O=C(OCC1=CC=C(F)C=C1)N(C2=NC(NC3=CN(C)N=C3)=NC=C2)C4=CC=CC(NC(C=C)=O)=C4
Molecular Weight
487.49
References & Citations
[1]Jang J,et al. Discovery of a Highly Potent and Broadly Effective Epidermal Growth Factor Receptor and HER2 Exon 20 Insertion Mutant Inhibitor. Angew Chem Int Ed Engl. 2018 Sep 3;57(36):11629-11633.
Shipping Conditions
Room temperature
Product Datasheet
http://file.medchemexpress.com/batch_PDF/HY-123766/EGFR-IN-99-DataSheet-MedChemExpress.pdf
Product MSDS
http://file.medchemexpress.com/batch_PDF/HY-123766/
Clinical Information
No Development Reported
CAS Number
2068806-31-3
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