PD-156707

PD-156707 is an orally active, nonpeptide and selective Endothelin-A receptor antagonist. PD-156707 binds to human ET-A and ET-B receptors with Ki values of 0.17 nM and 133.8 nM, respectively. PD-156707 shows reversal of established chronic hypoxic pulmonary hypertension in rats. PD-156707 can be used for the study of diseases associated with abnormal ET-A receptor activation, particularly pulmonary hypertension, stroke, and heart failure[1][2].

Product Specifications

CAS Number

[162412-70-6]

UNSPSC

12352005

Hazard Statement

H410

Target

Endothelin Receptor

Type

Reference compound

Related Pathways

GPCR/G Protein

Applications

Neuroscience-Neuromodulation

Field of Research

Neurological Disease; Cardiovascular Disease

Assay Protocol

https://www.medchemexpress.com/pd-156707.html

Purity

99.92

Solubility

10 mM in DMSO

Smiles

O=C(/C(C1=CC=C2OCOC2=C1)=C(C(C3=CC=C(C=C3)OC)=O)/CC4=CC(OC)=C(C(OC)=C4)OC)O[Na]

Molecular Formula

C28H25NaO9

Molecular Weight

528.48

Precautions

H410

References & Citations

[1]Andrew C. G. Uprichard, et al. PD- 156707: A Selective Endothelin-A Receptor Antagonist. Cardiovascular Drug Reviews Vol. 16, No. 2, pp. 89-104.|[2]D P Ignasiak, et al. Effects of endothelin ETA receptor antagonism with PD 156707 on hemodynamics and renal vascular resistance in rabbits. Eur J Pharmacol. 1997 Mar 5;321 (3) :295-300.