RDR03871

RDR03871 (compound 2) is a potent dual MDM2/MDM4 inhibitor with IC50 values of 35.4 nM and 10.4 nM for MDM2-p53 and MDM4-p53, respectively[1].

Product Specifications

CAS Number

[286008-51-3]

UNSPSC

12352005

Target

MDM-2/p53

Type

Reference compound

Related Pathways

Apoptosis

Applications

Cancer-programmed cell death

Field of Research

Cancer

Assay Protocol

https://www.medchemexpress.com/rdr03871.html

Solubility

10 mM in DMSO

Smiles

FC(F)(F)C1=CC=CC(NCCNC2=NC(C3=NC=CC=C3)=NC(C)=C2Cl)=N1

Molecular Formula

C18H16ClF3N6

Molecular Weight

408.81

References & Citations

[1]Mariateresa Giustiniano, et al. Computer-Aided Identification and Lead Optimization of Dual Murine Double Minute 2 and 4 Binders: Structure-Activity Relationship Studies and Pharmacological Activity. J Med Chem. 2017 Oct 12;60 (19) :8115-8130.

Shipping Conditions

Room temperature

Scientific Category

Reference compound1

Clinical Information

No Development Reported

Available Sizes

Curated Selection

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