CRT 0105446
Product Specifications
UNSPSC Description
CRT 0105446 (compound 22d) is a LIMK1 inhibitor, with an IC50 of 8 nM[1].
Target Antigen
LIM Kinase (LIMK)
Type
Reference compound
Related Pathways
Cell Cycle/DNA Damage
Applications
Cancer-Kinase/protease
Field of Research
Cancer
Assay Protocol
https://www.medchemexpress.com/crt-0105446.html
Solubility
10 mM in DMSO
Smiles
CC(C(NC1=NC=C(S1)C2=C(C=NC=C2)C3=CC=C(C=C3C(F)(F)F)OC)=O)C
Molecular Weight
421.44
References & Citations
[1]Mark D Charles, et al. Discovery, Development, and SAR of Aminothiazoles as LIMK Inhibitors with Cellular Anti-Invasive Properties. J Med Chem. 2015 Oct 22;58(20):8309-13.
Shipping Conditions
Room temperature
Product Datasheet
http://file.medchemexpress.com/batch_PDF/HY-123345/CRT-0105446-DataSheet-MedChemExpress.pdf
Product MSDS
http://file.medchemexpress.com/batch_PDF/HY-123345/
Clinical Information
No Development Reported
CAS Number
1661846-05-4
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