Cardiogenol C

Cardiogenol C is a potent cell-permeable pyrimidine inducer which prompts the differentiation of ESCs into cardiomyocytes (EC50=100 nM) [1]. Cardiogenol C also acts cardiomyogenic on already lineage-committed progenitor cell types with a limited degree of plasticity. Cardiogenol C is a useful cardiomyogenic agent and can be used as a tool to improve cardiac repair by cell transplantation therapy in animal models[2].

Product Specifications

CAS Number

[671225-39-1]

UNSPSC

12352005

Hazard Statement

H302

Target

Wnt; β-catenin

Type

Reference compound

Related Pathways

Stem Cell/Wnt

Applications

Cancer-programmed cell death

Field of Research

Cancer

Assay Protocol

https://www.medchemexpress.com/cardiogenol-c.html

Solubility

10 mM in DMSO

Smiles

COC1=CC=C(NC2=NC=CC(NCCO)=N2)C=C1

Molecular Formula

C13H16N4O2

Molecular Weight

260.29

Precautions

P264-P270-P330-P501

References & Citations

[1]Wu X, et al. Small molecules that induce cardiomyogenesis in embryonic stem cells.J Am Chem Soc. 2004 Feb 18;126 (6) :1590-1.|[2]Mike AK, et al. Small molecule cardiogenol C upregulates cardiac markers and induces cardiac functional properties in lineage-committed progenitor cells. Cell Physiol Biochem. 2014;33 (1) :205-21.